Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice

@article{Hill2008ArthritisIB,
  title={Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice},
  author={Jonathan A. Hill and David A. Bell and William Brintnell and David Yue and Bret Michael Wehrli and Anthony M Jevnikar and David M Lee and Wolfgang Hueber and William H Robinson and Ewa Cairns},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={967 - 979}
}
Rheumatoid arthritis (RA) is a common autoimmune disease that afflicts the synovium of diarthrodial joints. The pathogenic mechanisms inciting this disease are not fully characterized, but may involve the loss of tolerance to posttranslationally modified (citrullinated) antigens. We have demonstrated that this modification leads to a selective increase in antigenic peptide affinity for major histocompatibility complex (MHC) class II molecules that carry the RA-associated shared epitope, such as… CONTINUE READING