Arthritis and Pain. Neurogenic origin of joint pain

  title={Arthritis and Pain. Neurogenic origin of joint pain},
  author={Jason J McDougall},
  journal={Arthritis Research & Therapy},
  pages={220 - 220}
Arthritis pain affects millions of people worldwide yet we still have only a limited understanding of what makes our joints ache. This review examines the sensory innervation of diarthroidal joints and discusses the neurophysiological processes that lead to the generation of painful sensation. During inflammation, joint nerves become sensitized to mechanical stimuli through the actions of neuropeptides, eicosanoids, proteinase-activated receptors and ion channel ligands. The contribution of… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 80 extracted citations

Neuropeptides: important regulators of joint homeostasis

Knee Surgery, Sports Traumatology, Arthroscopy • 2018
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 112 references

Calcium channels as therapeutic targets in neuropathic pain.

The journal of pain : official journal of the American Pain Society • 2006

Similar Papers

Loading similar papers…