Arthritic calcitonin/alpha calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivity.

@article{Zhang2001ArthriticCC,
  title={Arthritic calcitonin/alpha calcitonin gene-related peptide knockout mice have reduced nociceptive hypersensitivity.},
  author={Ling Zhang and Ana de Oliveira Hoff and Sunil J. Wimalawansa and G. J. Cote and R. F. Gagel and Karin N. Westlund},
  journal={Pain},
  year={2001},
  volume={89 2-3},
  pages={265-73}
}
Peripheral inflammation induced with a knee joint injection of a mixture of kaolin/carrageenan (k/c) produces primary and secondary hyperalgesia. Inflammatory pain is thought to involve a variety of transmitters released from nerve terminals, including amino acids, substance P (SP) and calcitonin gene-related peptide (CGRP). In the present study, mice deficient in the calcitonin/alpha CGRP gene (CGRP(-/-)) displayed normal responses to noxious stimuli. However, the CGRP knockout mice failed to… CONTINUE READING