Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial

@article{Dondorp2005ArtesunateVQ,
  title={Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial},
  author={A. Dondorp and F. Nosten and K. Stepniewska and N. Day and N. White},
  journal={The Lancet},
  year={2005},
  volume={366},
  pages={717-725}
}
BACKGROUND In the treatment of severe malaria, intravenous artesunate is more rapidly acting than intravenous quinine in terms of parasite clearance, is safer, and is simpler to administer, but whether it can reduce mortality is uncertain. METHODS We did an open-label randomised controlled trial in patients admitted to hospital with severe falciparum malaria in Bangladesh, India, Indonesia, and Myanmar. We assigned individuals intravenous artesunate 2.4 mg/kg bodyweight given as a bolus (n… Expand

Paper Mentions

Observational Clinical Trial
- The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies. - Despite treatment between 10-30% of… Expand
ConditionsSevere Malaria
InterventionOther
Observational Clinical Trial
The MATIAS study aims to demonstrate through limited scope implementation studies how injectable artesunate may be progressively rolled out nationwide in the Democratic Republic… Expand
ConditionsSevere Malaria
InterventionOther
Comparison of artesunate and quinine in the treatment of severe Plasmodium falciparum malaria at Kassala hospital, Sudan.
TLDR
Artesunate is more effective than quinine, in term of parasite and fever clearance time, in the treatment of P. falciparum malaria in eastern Sudan, and in comatose patients, there was no difference between the two groups in coma resolution time. Expand
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
TLDR
Parenteral artesunate should replace quinine as the treatment of choice for severe falciparum malaria worldwide, according to evidence from Asia, and substantially reduces mortality in African children with severe malaria. Expand
Artesunate Dosing in Severe Falciparum Malaria
TLDR
A comparison of a once daily 4 mg/kg intravenous artesunate dose with the WHO-recommended regimen in African children hospitalized with malaria and the authors conclude that a simple 24-hour, 3-dose regimen should be further studied and developed to licensure for treating severe malaria in children are think that this conclusion is not valid and that it could be dangerous. Expand
Artesunate Suppositories versus Intramuscular Artemether for Treatment of Severe Malaria in Children in Papua New Guinea
TLDR
In severely ill children with malaria in PNG, artesunate suppositories were at least as effective as i.m. artemether and may, therefore, be useful in settings where parenteral therapy cannot be given. Expand
A simplified intravenous artesunate regimen for severe malaria.
TLDR
Pharmacodynamic analysis suggests that 3 doses of artesunate were not inferior to 5 doses for the treatment of severe malaria in children. Expand
Intravenous artesunate plus Artemisnin based Combination Therapy (ACT) or intravenous quinine plus ACT for treatment of severe malaria in Ugandan children: a randomized controlled clinical trial
TLDR
In this high transmission setting, adequate initial treatment outcomes are observed followed by very high rates of malaria re-infection post severe malaria treatment, which needs to be investigated and surveillance mechanisms for resistance markers established. Expand
Randomized controlled trial of artesunate or artemether in Vietnamese adults with severe falciparum malaria
TLDR
Intramuscular artesunate may be superior to intramusclescular artemether for the treatment of severe malaria in adults with severe falciparum malaria. Expand
Parenteral artesunate reduced inhospital mortality more than quinine in severe falciparum malaria
TLDR
Patients were allocated to intravenous artesunate or quinine dihydrochloride, 20 mg/kg loading dose infused over 4 hours (in 500 ml of 5% dextrose water or 0.9% saline), and then 10mg/kg infused over 228 hours 3 times/day until oral quinines could be taken. Expand
Artesunate versus quinine for treating severe malaria.
TLDR
The evidence clearly supports the superiority of parenteral artesunate over quinine for the treatment of severe malaria in both adults and children and in different regions of the world. Expand
Intravenous artesunate versus intravenous quinine in the treatment of severe falciparum malaria: a retrospective evaluation from a UK centre
TLDR
IV AS is found to be safe and effective, with shorter LOS, faster parasite and fever clearance, no fatalities or hypoglycaemic events, and fewer ICU admissions versus IV Q, corroborates both developing world trials and smaller European case series. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 42 REFERENCES
Randomized comparison of artesunate and quinine in the treatment of severe falciparum malaria.
  • P. Newton, B. Angus, +7 authors N. White
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2003
TLDR
A randomized, open-label comparison of artesunate and quinine was conducted in 113 adults with clinically severe falciparum malaria in western Thailand, and it was found that artes unate is at least as effective in the treatment of adults with severe malaria. Expand
Comparison of artemisinin suppositories, intramuscular artesunate and intravenous quinine for the treatment of severe childhood malaria.
TLDR
Artemisinin suppositories are easy to administer, cheap, and very effective for treating children with severe malaria and in rural areas where medical facilities are lacking these drugs will allow antimalarial therapy to be instituted earlier in the course of the disease and may therefore save lives. Expand
A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria.
TLDR
Artemether is a satisfactory alternative to quinine for the treatment of severe malaria in adults in Vietnam and is associated with a higher risk of hypoglycemia, but there were no other serious side effects in either group. Expand
Comparison of artemisinin suppositories with intravenous artesunate and intravenous quinine in the treatment of cerebral malaria.
TLDR
It is demonstrated that artemisinin suppositories are as effective as artesunate and quinine given intravenously, and have economic and practical advantages for the treatment of severe malaria in areas remote from major medical centres, but large numbers of patients will need to be studied if differences in mortality between the 3 treatment groups are to be demonstrated. Expand
Artesunate combinations for treatment of malaria: meta-analysis
TLDR
The addition of 3 days of artesunate to standard antimalarial treatments substantially reduce treatment failure, recrudescence, and gametocyte carriage. Expand
A trial of artemether or quinine in children with cerebral malaria.
TLDR
Artemether is as effective as quinine in the treatment of cerebral malaria in children, and residual neurologic sequelae are detected in 576 Gambian children analyzed at approximately five months for neurologic disease. Expand
Intramuscular Bioavailability and Clinical Efficacy of Artesunate in Gabonese Children with Severe Malaria
TLDR
The pharmacokinetics and bioavailability of ARS given by the intramuscular route support the use of i.m. ARS in children with severe malaria. Expand
Quinine in severe falciparum malaria: evidence of declining efficacy in Thailand.
TLDR
Quinine remains an effective treatment for severe multi-drug resistant falciparum malaria in this area, but there is now evidence of a decline in the immediate therapeutic response, and its efficacy will need close monitoring as resistance increases further. Expand
Comparison of combinations of parenteral artemisinin derivatives plus oral mefloquine with intravenous quinine plus oral tetracycline for treating cerebral malaria.
A total of 141 cases of strictly defined cerebral malaria were studied in a controlled trial of three regimens: (1) intramuscular artemether plus oral mefloquine, (2) intravenous artesunate plus oralExpand
Artemether Bioavailability after Oral or Intramuscular Administration in Uncomplicated Falciparum Malaria
ABSTRACT The antimalarial activity of artemether following oral or intramuscular administration in the plasma of 15 adults with acute uncomplicated Plasmodium falciparum malaria was measured byExpand
...
1
2
3
4
5
...