Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial

@article{Dondorp2005ArtesunateVQ,
  title={Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial},
  author={A. Dondorp and F. Nosten and K. Stepniewska and N. Day and N. White},
  journal={The Lancet},
  year={2005},
  volume={366},
  pages={717-725}
}
BACKGROUND In the treatment of severe malaria, intravenous artesunate is more rapidly acting than intravenous quinine in terms of parasite clearance, is safer, and is simpler to administer, but whether it can reduce mortality is uncertain. METHODS We did an open-label randomised controlled trial in patients admitted to hospital with severe falciparum malaria in Bangladesh, India, Indonesia, and Myanmar. We assigned individuals intravenous artesunate 2.4 mg/kg bodyweight given as a bolus (n… Expand
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Intramuscular artesunate may be superior to intramusclescular artemether for the treatment of severe malaria in adults with severe falciparum malaria. Expand
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The evidence clearly supports the superiority of parenteral artesunate over quinine for the treatment of severe malaria in both adults and children and in different regions of the world. Expand
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IV AS is found to be safe and effective, with shorter LOS, faster parasite and fever clearance, no fatalities or hypoglycaemic events, and fewer ICU admissions versus IV Q, corroborates both developing world trials and smaller European case series. Expand
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