Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
@article{Dondorp2005ArtesunateVQ, title={Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial}, author={Arjen M. Dondorp and François Nosten and Kasia Stepniewska and Nicholas Day and Nick White}, journal={The Lancet}, year={2005}, volume={366}, pages={717-725} }
957 Citations
Comparison of artesunate and quinine in the treatment of severe Plasmodium falciparum malaria at Kassala hospital, Sudan.
- MedicineJournal of infection in developing countries
- 2014
Artesunate is more effective than quinine, in term of parasite and fever clearance time, in the treatment of P. falciparum malaria in eastern Sudan, and in comatose patients, there was no difference between the two groups in coma resolution time.
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
- MedicineThe Lancet
- 2010
Artesunate Dosing in Severe Falciparum Malaria
- MedicineThe Journal of infectious diseases
- 2012
A comparison of a once daily 4 mg/kg intravenous artesunate dose with the WHO-recommended regimen in African children hospitalized with malaria and the authors conclude that a simple 24-hour, 3-dose regimen should be further studied and developed to licensure for treating severe malaria in children are think that this conclusion is not valid and that it could be dangerous.
Artesunate Suppositories versus Intramuscular Artemether for Treatment of Severe Malaria in Children in Papua New Guinea
- MedicineAntimicrobial Agents and Chemotherapy
- 2006
In severely ill children with malaria in PNG, artesunate suppositories were at least as effective as i.m. artemether and may, therefore, be useful in settings where parenteral therapy cannot be given.
A simplified intravenous artesunate regimen for severe malaria.
- MedicineThe Journal of infectious diseases
- 2012
Pharmacodynamic analysis suggests that 3 doses of artesunate were not inferior to 5 doses for the treatment of severe malaria in children.
Intravenous artesunate plus Artemisnin based Combination Therapy (ACT) or intravenous quinine plus ACT for treatment of severe malaria in Ugandan children: a randomized controlled clinical trial
- MedicineBMC Infectious Diseases
- 2017
In this high transmission setting, adequate initial treatment outcomes are observed followed by very high rates of malaria re-infection post severe malaria treatment, which needs to be investigated and surveillance mechanisms for resistance markers established.
Randomized controlled trial of artesunate or artemether in Vietnamese adults with severe falciparum malaria
- Medicine, PsychologyMalaria Journal
- 2010
Intramuscular artesunate may be superior to intramusclescular artemether for the treatment of severe malaria in adults with severe falciparum malaria.
Parenteral artesunate reduced inhospital mortality more than quinine in severe falciparum malaria
- MedicineEvidence-based medicine
- 2006
Patients were allocated to intravenous artesunate or quinine dihydrochloride, 20 mg/kg loading dose infused over 4 hours (in 500 ml of 5% dextrose water or 0.9% saline), and then 10mg/kg infused over 228 hours 3 times/day until oral quinines could be taken.
Artesunate versus quinine for treating severe malaria.
- MedicineThe Cochrane database of systematic reviews
- 2012
The evidence clearly supports the superiority of parenteral artesunate over quinine for the treatment of severe malaria in both adults and children and in different regions of the world.
Intravenous artesunate versus intravenous quinine in the treatment of severe falciparum malaria: a retrospective evaluation from a UK centre
- MedicinePathogens and global health
- 2012
IV AS is found to be safe and effective, with shorter LOS, faster parasite and fever clearance, no fatalities or hypoglycaemic events, and fewer ICU admissions versus IV Q, corroborates both developing world trials and smaller European case series.
References
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A randomized, open-label comparison of artesunate and quinine was conducted in 113 adults with clinically severe falciparum malaria in western Thailand, and it was found that artes unate is at least as effective in the treatment of adults with severe malaria.
Comparison of artemisinin suppositories, intramuscular artesunate and intravenous quinine for the treatment of severe childhood malaria.
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A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria.
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Artemether is a satisfactory alternative to quinine for the treatment of severe malaria in adults in Vietnam and is associated with a higher risk of hypoglycemia, but there were no other serious side effects in either group.
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A trial of artemether or quinine in children with cerebral malaria.
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Artemether is as effective as quinine in the treatment of cerebral malaria in children, and residual neurologic sequelae are detected in 576 Gambian children analyzed at approximately five months for neurologic disease.
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The pharmacokinetics and bioavailability of ARS given by the intramuscular route support the use of i.m. ARS in children with severe malaria.
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Artemether Bioavailability after Oral or Intramuscular Administration in Uncomplicated Falciparum Malaria
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ABSTRACT The antimalarial activity of artemether following oral or intramuscular administration in the plasma of 15 adults with acute uncomplicated Plasmodium falciparum malaria was measured by…
A randomized controlled trial comparing artemether and quinine in the treatment of cerebral malaria in Bangladesh.
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Results of the study suggest that treatment with artemether is as effective as parenteral quinine in the treatment of cerebral malaria in adults.