Artesunate Induces ROS-Mediated Apoptosis in Doxorubicin-Resistant T Leukemia Cells

@article{Efferth2007ArtesunateIR,
  title={Artesunate Induces ROS-Mediated Apoptosis in Doxorubicin-Resistant T Leukemia Cells},
  author={Thomas H Efferth and Marco Giaisi and Annette Merling and Peter Heinrich Krammer and Min Li-Weber},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={110 - 111}
}
BACKGROUND A major obstacle for successful cancer treatment often is the development of drug resistance in cancer cells during chemotherapy. Therefore, there is an urgent need for novel drugs with improved efficacy against tumor cells and with less toxicity on normal cells. Artesunate (ART), a powerful anti-malarial herbal compound, has been shown to inhibit growth of various tumor cell lines in vitro and of xenografted Kaposi's sarcoma in mice in vivo. However, the molecular mechanisms by… CONTINUE READING

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