Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin β Receptors.

@article{Hu2015ArteryTL,
  title={Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin β Receptors.},
  author={Desheng Hu and Sarajo Mohanta and Changjun Yin and Li Peng and Zhe Ma and Prasad Srikakulapu and Gianluca Grassia and Neil Macritchie and Gary Dever and P{\'e}ter Gordon and Francis L. Burton and Armando Ialenti and Suleman R. Sabir and Iain B. Mcinnes and James M Brewer and Paul G Garside and Christian Weber and Thomas R. Lehmann and Daniel Teupser and Livia Habenicht and Michael Beer and Rolf Grabner and Pasquale Maffia and Falk Weih and Andreas J. R. Habenicht},
  journal={Immunity},
  year={2015},
  volume={42 6},
  pages={1100-15}
}
Tertiary lymphoid organs (TLOs) emerge during nonresolving peripheral inflammation, but their impact on disease progression remains unknown. We have found in aged Apoe(-/-) mice that artery TLOs (ATLOs) controlled highly territorialized aorta T cell responses. ATLOs promoted T cell recruitment, primed CD4(+) T cells, generated CD4(+), CD8(+), T regulatory (Treg) effector and central memory cells, converted naive CD4(+) T cells into induced Treg cells, and presented antigen by an unusual set of… CONTINUE READING

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