Arteriojugular endothelin-1 gradients in aneurysmal subarachnoid haemorrhage.

  title={Arteriojugular endothelin-1 gradients in aneurysmal subarachnoid haemorrhage.},
  author={David K. Menon and Diana D Day and Rhoda E. Kuc and Andrew J Downie and Doris A. Chatfield and Anthony P. Davenport},
  journal={Clinical science},
  volume={103 Suppl 48},
Plasma endothelin (ET) is elevated in patients with vasospasm following subarachnoid haemorrhage (SAH). However, systemic levels provide no indication regarding local production in the brain, and late elevation may be a consequence rather than a cause of vasospasm. We measured arteriojugular (AJ) gradients of ET-1 in 17 patients over the first week after SAH, and related these to the subsequent development of vasospasm. Daily, paired arterial and jugular bulb blood samples were obtained up to… CONTINUE READING

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