Arterially delivered mesenchymal stem cells prevent obstruction-induced renal fibrosis.

@article{Asanuma2011ArteriallyDM,
  title={Arterially delivered mesenchymal stem cells prevent obstruction-induced renal fibrosis.},
  author={Hiroshi Asanuma and Brian A. Vanderbrink and Matthew T. Campbell and Karen L. Hile and Hongji Zhang and Daniel R. Meldrum and Kirstan K. Meldrum},
  journal={The Journal of surgical research},
  year={2011},
  volume={168 1},
  pages={e51-9}
}
BACKGROUND Mesenchymal stem cells (MSCs) hold promise for the treatment of renal disease. While MSCs have been shown to accelerate recovery and prevent acute renal failure in multiple disease models, the effect of MSC therapy on chronic obstruction-induced renal fibrosis has not previously been evaluated. MATERIALS AND METHODS Male Sprague-Dawley rats underwent renal artery injection of vehicle or fluorescent-labeled human bone marrow-derived MSCs immediately prior to sham operation or… CONTINUE READING

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