Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2.

@article{Dieffenbach2017ArterialSI,
  title={Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2.},
  author={Paul B. Dieffenbach and Christina Mallarino Haeger and Anna Maria F Coronata and Kyoung Moo Choi and Xaralabos Varelas and Daniel J Tschumperlin and Laura E Fredenburgh},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2017},
  volume={313 3},
  pages={
          L628-L647
        }
}
Pulmonary arterial stiffness is an independent risk factor for mortality in pulmonary hypertension (PH) and plays a critical role in PH pathophysiology. Our laboratory has recently demonstrated arterial stiffening early in experimental PH, along with evidence for a mechanobiological feedback loop by which arterial stiffening promotes further cellular remodeling behaviors (Liu F, Haeger CM, Dieffenbach PB, Sicard D, Chrobak I, Coronata AM, Suárez Velandia MM, Vitali S, Colas RA, Norris PC… CONTINUE READING
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