Arterial stiffness and cerebral small vessel disease: the Rotterdam Scan Study.

  title={Arterial stiffness and cerebral small vessel disease: the Rotterdam Scan Study.},
  author={Mari{\"e}lle M. F. Poels and K{\`e}ren Zaccai and Germaine C. Verwoert and Meike W. Vernooij and Albert Hofman and Aad van der Lugt and Jacqueline C. M. Witteman and Monique M. B. Breteler and Francesco U. S. Mattace-Raso and M. Arfan Ikram},
  volume={43 10},
BACKGROUND AND PURPOSE Aging and vascular risk factors contribute to arterial stiffening. Increased arterial stiffness exposes the small vessels in the brain to abnormal flow pulsations and, as such, may contribute to the pathogenesis of cerebral small vessel disease. In a population-based study, we investigated the association between arterial stiffness, as measured by aortic pulse wave velocity (aPWV), and small vessel disease. METHODS Overall, 1460 participants (mean age, 58.2 years… CONTINUE READING
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