Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility--Reykjavik study.

@article{Mitchell2011ArterialSP,
  title={Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility--Reykjavik study.},
  author={Gary F. Mitchell and Mark A. van Buchem and Sigurdur E Sigurdsson and John D. Gotal and Mar{\'i}a K J{\'o}nsd{\'o}ttir and {\'O}lafur Kjartansson and Melissa E. Garcia and Thor Aspelund and Tamara B. Harris and Vilmundur Gudnason and Lenore J. Launer},
  journal={Brain : a journal of neurology},
  year={2011},
  volume={134 Pt 11},
  pages={3398-407}
}
Aortic stiffness increases with age and vascular risk factor exposure and is associated with increased risk for structural and functional abnormalities in the brain. High ambient flow and low impedance are thought to sensitize the cerebral microcirculation to harmful effects of excessive pressure and flow pulsatility. However, haemodynamic mechanisms contributing to structural brain lesions and cognitive impairment in the presence of high aortic stiffness remain unclear. We hypothesized that… CONTINUE READING
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