Arterial smooth muscle cells in primary culture produce a platelet-derived growth factor-like protein.

@article{Nilsson1985ArterialSM,
  title={Arterial smooth muscle cells in primary culture produce a platelet-derived growth factor-like protein.},
  author={Jan Nilsson and Maria Sj{\"o}lund and Lena Palmberg and Johan Thyberg and Carl-Henrik Heldin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 13},
  pages={4418-22}
}
Adult rat arterial smooth muscle cells (SMC) in primary culture modulate from contractile to synthetic phenotype. This process includes partial loss of myofilaments and formation of an extensive rough endoplasmic reticulum and a large Golgi complex. It gives the cells the ability to initiate DNA synthesis and actively proliferate when stimulated with serum or isolated growth factors. After a few divisions, growth becomes partly independent of exogenous mitogens and does not cease until multiple… CONTINUE READING

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