Arterial nicotine kinetics during cigarette smoking and intravenous nicotine administration: implications for addiction.

@article{Rose1999ArterialNK,
  title={Arterial nicotine kinetics during cigarette smoking and intravenous nicotine administration: implications for addiction.},
  author={Jed E. Rose and Fr{\'e}d{\'e}rique M. Behm and Eric C Westman and R. Edward Coleman},
  journal={Drug and alcohol dependence},
  year={1999},
  volume={56 2},
  pages={99-107}
}
An understanding of drug addiction requires knowledge of the effective drug concentrations to which receptors in the nervous system are exposed. It has often been thought that smoking of abused substances such as nicotine or cocaine produces much higher drug concentrations in the arterial blood than those achieved following any other route of administration. However, to date no studies have sampled arterial blood following cigarette smoking with the rapidity necessary to evaluate this… CONTINUE READING

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