Arterial flow reduces oxidative stress via an antioxidant response element and Oct-1 binding site within the NADPH oxidase 4 promoter in endothelial cells

@article{Goettsch2011ArterialFR,
  title={Arterial flow reduces oxidative stress via an antioxidant response element and Oct-1 binding site within the NADPH oxidase 4 promoter in endothelial cells},
  author={Claudia Goettsch and Winfried Goettsch and Melanie Brux and Claudia Haschke and Coy Brunssen and Gregor Muller and Stefan R. Bornstein and Nicole Duerrschmidt and Andreas H Wagner and Henning Morawietz},
  journal={Basic Research in Cardiology},
  year={2011},
  volume={106},
  pages={551-561}
}
The main sources of oxidative stress in the vessel wall are nicotine adenine dinucleotide phosphate (NADPH) oxidase (Nox) complexes. The endothelium mainly expresses the Nox4-containing complex; however, the mechanism by which shear stress in endothelial cells regulates Nox4 is not well understood. This study demonstrates that long-term application of arterial laminar shear stress using a cone-and-plate viscometer reduces endothelial superoxide anion formation and Nox4 expression. In primary… CONTINUE READING