Arterial dysgenesis and limb defects: Clinical and experimental examples.

@article{Vargesson2017ArterialDA,
  title={Arterial dysgenesis and limb defects: Clinical and experimental examples.},
  author={Neil Vargesson and David R Hootnick},
  journal={Reproductive toxicology},
  year={2017},
  volume={70},
  pages={
          21-29
        }
}
Limb malformations are amongst the most common and visible birth effects. Causes have been purported to include genetic aberrations as well as teratogens, such as thalidomide. Here we review the evidence for vascular disruption in the genesis of limb malformations through abnormal arterial transitioning and from events such as amniocentesis, uterine constriction, and through teratogen exposure. We use several clinical and experimental examples and highlight the need to understand more about the… CONTINUE READING
1
Twitter Mention

References

Publications referenced by this paper.
SHOWING 1-10 OF 75 REFERENCES

Computed tomographic angiography in proximal femoral focal deficiency.

  • The Journal of bone and joint surgery. American volume
  • 2009
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Teratogen-induced limb defects.

  • American journal of medical genetics
  • 2002
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

An interpretation of the recorded arterial anomalies of the human leg and foot

H. D. Senior
  • J 389 Anat
  • 1919
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

role of the TGFbeta 366 signaling pathway

N. Vargesson, Vascularisation of the developing chick limb bud
  • J Anat. 202
  • 2003
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Hootnick, Extent of duplication in lower-limb 465 malformations suggests the time of the teratogenic insult

D. S. Packard, D.R.E.M. Levinsohn
  • Pediatrics
  • 1993
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Hootnick, Most human lower limb malformations 409 appear to result from postspecification insults

D. S. Packard, D.R.E.M. Levinsohn
  • Prog Clin Biol Res
  • 1993
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL