Arterial Smooth Muscle Mitochondria Amplify Hydrogen Peroxide Microdomains Functionally Coupled to L-Type Calcium Channels.

@article{Chaplin2015ArterialSM,
  title={Arterial Smooth Muscle Mitochondria Amplify Hydrogen Peroxide Microdomains Functionally Coupled to L-Type Calcium Channels.},
  author={Nathan L Chaplin and Madeline Nieves-Cintr{\'o}n and Adriana M Fresquez and Manuel F. Navedo and Gregory C Amberg},
  journal={Circulation research},
  year={2015},
  volume={117 12},
  pages={1013-23}
}
RATIONALE Mitochondria are key integrators of convergent intracellular signaling pathways. Two important second messengers modulated by mitochondria are calcium and reactive oxygen species. To date, coherent mechanisms describing mitochondrial integration of calcium and oxidative signaling in arterial smooth muscle are incomplete. OBJECTIVE To address and add clarity to this issue, we tested the hypothesis that mitochondria regulate subplasmalemmal calcium and hydrogen peroxide microdomain… CONTINUE READING
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