Arterial Flow Regulator Enables Transplantation and Growth of Human Fetal Kidneys in Rats

  title={Arterial Flow Regulator Enables Transplantation and Growth of Human Fetal Kidneys in Rats},
  author={N K Chang and Jl. Gu and S Gu and Robert W. Osorio and Waldo Concepci{\'o}n and E Gu},
  journal={American Journal of Transplantation},
  • N. Chang, J. Gu, +3 authors E. Gu
  • Published 2015
  • Medicine
  • American Journal of Transplantation
Here we introduce a novel method of transplanting human fetal kidneys into adult rats. To overcome the technical challenges of fetal‐to‐adult organ transplantation, we devised an arterial flow regulator (AFR), consisting of a volume adjustable saline‐filled cuff, which enables low‐pressure human fetal kidneys to be transplanted into high‐pressure adult rat hosts. By incrementally withdrawing saline from the AFR over time, blood flow entering the human fetal kidney was gradually increased until… Expand
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