Artemisinins: mechanisms of action and potential for resistance.

  title={Artemisinins: mechanisms of action and potential for resistance.},
  author={Sanjeev Krishna and A C Uhlemann and Richard K. Haynes},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  volume={7 4-5},
Artemisinins form the most important class of antimalarial currently available, particularly because they are effective against parasites resistant to almost all the other classes. Their mechanism of action is controversial. Some aspects of this controversy are reviewed here. Whilst there is no clinical resistance yet identified to artemisinins, the potential to examine the relationship between polymorphisms in PfATP6 (a target of artemisinins) in multidrug resistant isolates of Plasmodium… CONTINUE READING

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