Artemisinin population pharmacokinetics in children and adults with uncomplicated falciparum malaria.

@article{Sidhu1998ArtemisininPP,
  title={Artemisinin population pharmacokinetics in children and adults with uncomplicated falciparum malaria.},
  author={Jadvinder Singh Sidhu and Michael Ashton and Nguyen van Huong and T. N. Hai and Mats O. Karlsson and N D Sy and E. Niclas Jonsson and Le Dinh Cong},
  journal={British journal of clinical pharmacology},
  year={1998},
  volume={45 4},
  pages={347-54}
}
AIMS To investigate the pharmacokinetics of the antimalarial artemisinin in the field setting using sparsely collected data. METHODS Artemisinin concentrations were determined by h.p.l.c. in a total of 107 capillary plasma samples collected on the first day and in 33 samples on the last day of a 5-day oral artemisinin regimen of 10 mg kg(-1) day(-1) in 23 paediatric (aged 2-12 years) and 31 adult (aged 16-45 years) Vietnamese patients with uncomplicated falciparum malaria. The population… CONTINUE READING

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