Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation.

  title={Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation.},
  author={Elisabetta Aldieri and Daniela Atragene and Loredana Bergandi and Chiara Riganti and Costanzo Costamagna and Amalia Bosia and Dario Ghigo},
  journal={FEBS letters},
  volume={552 2-3},
Artemisinin is a natural product used as an alternative drug in the treatment of severe and multidrug-resistant malaria. In the present work we show that artemisinin shares with other sesquiterpene lactones the ability to inhibit the activation of the nuclear factor NF-kB: by this mechanism, artemisinin, as well as parthenolide, inhibits nitric oxide synthesis in cytokine-stimulated human astrocytoma T67 cells. These results suggest that artemisinin, in addition to its antiparasitic properties… CONTINUE READING


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