Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression.

@article{Riganti2009ArtemisininID,
  title={Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression.},
  author={Chiara Riganti and Sophie Doublier and Daniele Viarisio and Erica Miraglia and Gianpiero Pescarmona and Dario Ghigo and Amalia Bosia},
  journal={British journal of pharmacology},
  year={2009},
  volume={156 7},
  pages={1054-66}
}
BACKGROUND AND PURPOSE Artemisinin is an antimalarial drug exerting pleiotropic effects, such as the inhibition of the transcription factor nuclear factor-kappa B and of the sarcoplasmic/endoplasmic reticulum Ca(++)-ATPase (SERCA) of P. falciparum. As the sesquiterpene lactone thapsigargin, a known inhibitor of mammalian SERCA, enhances the expression of P-glycoprotein (Pgp) by increasing the intracellular Ca(++) ([Ca(++)](i)) level, we investigated whether artemisinin and its structural… CONTINUE READING
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