Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study.

@article{Mott2013ArtemisininderivedDP,
  title={Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study.},
  author={Bryan Thomas Mott and Ran He and Xiaochun Chen and Jennifer M. Fox and Curt I. Civin and Ravit Arav-Boger and Gary H. Posner},
  journal={Bioorganic & medicinal chemistry},
  year={2013},
  volume={21 13},
  pages={
          3702-7
        }
}
We recently reported the anti-cancer and anti-cytomegalovirus (CMV) activity of artemisinin-derived trioxane diphenylphosphate dimer 838. To probe the relationship between chemical structure and anti-CMV and anti-cancer activities, we now report synthesis and evaluation of a series of eight new dimer phosphate ester analogs of 838. This series of novel molecules was screened against human foreskin fibroblasts (HFFs) infected with CMV and against the human Jurkat T cell acute lymphoblastic… CONTINUE READING
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