Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle.

  title={Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle.},
  author={John G D'Angelo and Claudia Bord{\'o}n and Gary H. Posner and Robert Yolken and Lorraine Jones-Brando},
  journal={The Journal of antimicrobial chemotherapy},
  volume={63 1},
OBJECTIVES We sought to improve upon the usefulness of artemisinins as anti-Toxoplasma agents by synthesizing new unsaturated, carba derivatives and then testing them for in vitro efficacy against three steps of the lytic cycle of Toxoplasma gondii tachyzoites. METHODS Novel derivatives of ART were synthesized and then tested for in vitro antiparasitic activity using T. gondii tachyzoites constitutively expressing beta-galactosidase and human fibroblast host cells. Compounds were evaluated… CONTINUE READING

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