Artemisinin antimalarials: mechanisms of action and resistance.

  title={Artemisinin antimalarials: mechanisms of action and resistance.},
  author={Steven Richard Meshnick},
  journal={Medecine tropicale : revue du Corps de sante colonial},
  volume={58 3 Suppl},
Artemisinin derivatives are an important new class of antimalarial agents. These compounds contain endoperoxide bridges which are essential for antimalarial activity. Artemisinin is believed to act via a two-step mechanism. Artemisinin is first activated by intraparasitic heme-iron which catalyzes the cleavage of this endoperoxide. A resulting free radical intermediate may then kill the parasite by alkylating and poisoning one or more essential malarial protein(s). No clinically relevant… CONTINUE READING

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