Artemisians A-D, Diseco-guaianolide Involved Heterodimeric [4 + 2] Adducts from Artemisia argyi.

@article{Xue2017ArtemisiansAD,
  title={Artemisians A-D, Diseco-guaianolide Involved Heterodimeric [4 + 2] Adducts from Artemisia argyi.},
  author={Gui-Min Xue and Chao Han and Chen Chen and Ling-Nan Li and Xiao-Bing Wang and Ming-Hua Yang and Yu-Cheng Gu and Jian-guang Luo and Ling-yi Kong},
  journal={Organic letters},
  year={2017},
  volume={19 19},
  pages={
          5410-5413
        }
}
Artemisians A-D (1-4), the first examples of [4 + 2] Diels-Alder type adducts presumably biosynthesized from a rare 1, 10-4, 5-diseco-guaianolide and a guaianolide diene, along with their possible precursor 5, were isolated from the traditional Chinese medicine Artemisia argyi. The structures of 1-4 were elucidated by extensive spectroscopic analyses and calculated electronic circular dichroism. Compound 2, with an IC50 value of 3.21 μM, exhibited significant antiproliferative activity via… CONTINUE READING