Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.

@article{Geng2007ArtemisLA,
  title={Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.},
  author={Liyi Geng and Xiaoshan Zhang and Shu Yun Zheng and Randy J. Legerski},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 7},
  pages={2625-35}
}
Artemis is a phospho-protein that has been shown to have roles in V(D)J recombination, nonhomologous end-joining of double-strand breaks, and regulation of the DNA damage-induced G(2)/M cell cycle checkpoint. Here, we have identified four sites in Artemis that are phosphorylated in response to ionizing radiation (IR) and show that ATM is the major kinase responsible for these modifications. Two of the sites, S534 and S538, show rapid phosphorylation and dephosphorylation, and the other two… CONTINUE READING

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