Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.

Abstract

Mutations in Artemis in both humans and mice result in severe combined immunodeficiency due to a defect in V(D)J recombination. In addition, Artemis mutants are radiosensitive and chromosomally unstable, which has been attributed to a defect in nonhomologous end joining (NHEJ). We show here, however, that Artemis-depleted cell extracts are not defective in… (More)

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Cite this paper

@article{Zhang2004ArtemisIA, title={Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.}, author={Xiaoshan Zhang and Janice Succi and Zhaohui Feng and Sheela Prithivirajsingh and Michael Story and Randy J. Legerski}, journal={Molecular and cellular biology}, year={2004}, volume={24 20}, pages={9207-20} }