Artemin stimulates oncogenicity and invasiveness of human endometrial carcinoma cells.

@article{Pandey2010ArteminSO,
  title={Artemin stimulates oncogenicity and invasiveness of human endometrial carcinoma cells.},
  author={Vijay Pandey and Peng-Xu Qian and Jian Kang and Jo K Perry and Murray David Mitchell and Zhinan Yin and Zheng-Sheng Wu and Dong-Xu Liu and Tao Zhu and Peter E. Lobie},
  journal={Endocrinology},
  year={2010},
  volume={151 3},
  pages={909-20}
}
Here, we provide evidence for a functional role of artemin (ARTN) in progression of endometrial carcinoma (EC). Increased ARTN protein expression was observed in EC compared with normal endometrial tissue, and ARTN protein expression in EC was significantly associated with higher tumor grade and invasiveness. Forced expression of ARTN in EC cells significantly increased total cell number as a result of enhanced cell cycle progression and cell survival. In addition, forced expression of ARTN… CONTINUE READING

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