Artemin-GFRα3 interactions partially contribute to acute inflammatory hypersensitivity.

@article{Thornton2013ArteminGFR3IP,
  title={Artemin-GFRα3 interactions partially contribute to acute inflammatory hypersensitivity.},
  author={Peter H. Thornton and Jon P. Hatcher and Ian N. Robinson and Becky S Sargent and Bo Franz{\'e}n and Giovanni Martino and Lisa Kitching and Colin P. Glover and Dina B Anderson and Heidi Forsmo-Bruce and C. P. Low and Fiona S. Cusdin and Bhupinder Dosanjh and Wendy R. Williams and Ann-Charlott Steffen and Simon Giles Thompson and Malin B Eklund and Chris D. Lloyd and Iain Chessell and Jane Hughes},
  journal={Neuroscience letters},
  year={2013},
  volume={545},
  pages={23-8}
}
The expression of artemin (ARTN), a glial cell line-derived neurotrophic factor (GDNF) family ligand, increases in pre-clinical models of nociception and recent evidence suggests this growth factor may play a causative role in inflammatory pain mechanisms. The aim of this study was to demonstrate functional inhibition of ARTN with monoclonal antibodies and to determine whether ARTN neutralisation could reverse inflammatory pain in mice. We show that monoclonal antibodies with high affinity to… CONTINUE READING

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