Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology.

  title={Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology.},
  author={Olivier Toussaint and Geoffroy Weemaels and Florence Debacq-Chainiaux and Karin Scharffetter-Kochanek and Meinhard Wlaschek},
  journal={Journal of cellular physiology},
  volume={226 2},
In life sciences, modelling of the in vivo conditions using in vitro models is an important tool to generate knowledge. Although aerobic organisms including mammals depend on accurate oxygen tension, mimicking physiological conditions in cell culture experiments is not very common. Due to the need for simple technical and experimental design, the requirement for simulating the in vivo oxygen tension parameters has been neglected over long time. Fortunately, due to increasing knowledge in recent… CONTINUE READING
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