Artefacts in HPLC detection of 3-nitrotyrosine in human brain tissue.

@article{Kaur1998ArtefactsIH,
  title={Artefacts in HPLC detection of 3-nitrotyrosine in human brain tissue.},
  author={Harparkash Kaur and L Lyras and Peter Jenner and Barry Halliwell},
  journal={Journal of neurochemistry},
  year={1998},
  volume={70 5},
  pages={
          2220-3
        }
}
An HPLC method was used for quantification of 3-nitrotyrosine (3-NT) in human postmortem brain tissue. A peak with similar retention time to 3-NT was detected in brain tissue from patients with Parkinson's disease, Huntington's chorea, multiple system atrophy, and Alzheimer's disease but not in control tissue. The peak was lost on reduction with dithionite, a criterion often used to identify 3-NT. Tissue from the same neurodegenerative diseases was analysed by HPLC using a photodiode array… CONTINUE READING

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Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1998
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