ArtR, a novel sRNA of Staphylococcus aureus, regulates α-toxin expression by targeting the 5′ UTR of sarT mRNA

  title={ArtR, a novel sRNA of Staphylococcus aureus, regulates α-toxin expression by targeting the 5′ UTR of sarT mRNA},
  author={T. Xue and X. Zhang and Haipeng Sun and B. Sun},
  journal={Medical Microbiology and Immunology},
  • T. Xue, X. Zhang, +1 author B. Sun
  • Published 2013
  • Biology, Medicine
  • Medical Microbiology and Immunology
Recent studies point to the importance of small-noncoding RNAs (sRNAs) in bacterial virulence control. In Staphylococcus aureus, functional dissections of sRNAs are limited to RNA III, SprD, RsaE, SprA1, and SSR42 only. Here, we report the identification and functional analyses of a novel sRNA, which we have designated ArtR. Our data show that the AgrA protein can bind to the artR promoter and repress artR transcription, suggesting that, after RNA III, ArtR is the second sRNA regulated by AgrA… Expand
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