Arsenite-resistant Leishmania donovani promastigotes express an enhanced membrane P-type adenosine triphosphatase activity that is sensitive to verapamil treatment

@article{Prasad2000ArseniteresistantLD,
  title={Arsenite-resistant Leishmania donovani promastigotes express an enhanced membrane P-type adenosine triphosphatase activity that is sensitive to verapamil treatment},
  author={V R Shiva Prasad and Jaspreet Kaur and Chinmoy S. Dey},
  journal={Parasitology Research},
  year={2000},
  volume={86},
  pages={661-664}
}
An arsenite-resistant strain of Leishmania donovani was generated in vitro by sequential exposure to higher concentrations of sodium m-arsenite. The resistant strain displayed a low level of cross-resistance to structurally unrelated drugs such as doxorubicin and pentamidine. This cross-resistance was sensitive to the calcium-channel blocker verapamil. The… CONTINUE READING