Arsenite inhibits beta-oxidation in isolated rat liver mitochondria.

  title={Arsenite inhibits beta-oxidation in isolated rat liver mitochondria.},
  author={Kjell A. Rein and Borgar Borrebaek and Jon Bremer},
  journal={Biochimica et biophysica acta},
  volume={574 3},
A partial inhibition of acylcarnitine oxidation by arsenite in rat liver mitochondria has been studied. This inhibition is confined to the thiolase(s). The inhibition was observed also in the presence of malate, indicating no selective effect on ketogenesis. Ketogenesis from acetyl-CoA was inhibited by arsenite. Mitochondrial CoA was acylated by acylcarnitine nearly as rapidly in the presence of arsenite as in its absence. Thus, arsenite did not interfere with the availibility of CoA in the… CONTINUE READING