Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase.

@article{Hossain2000ArseniteIA,
  title={Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase.},
  author={Khaled Hossain and Anwarul Azim Akhand and Masashi Kato and Jun Du and Kohsuke Takeda and J C Wu and Kenji Takeuchi and Wei Liu and Haruhiko Suzuki and Izumi Nakashima},
  journal={Journal of immunology},
  year={2000},
  volume={165 8},
  pages={4290-7}
}
Because of its dual roles in acute toxicity and in therapeutic application in cancer treatment, arsenic has recently attracted a renewed attention. In this study, we report NaAsO(2)-induced signal cascades from the cell surface to the nucleus of murine thymic T lymphocytes that involve membrane rafts as an initial signal transducer. NaAsO(2) induced apoptosis through fragmentation of DNA, activation of caspase, and reciprocal regulation of Bcl-2/Bax with the concomitant reduction of membrane… CONTINUE READING

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