Arsenic trioxide uptake by human and rat aquaglyceroporins.

  title={Arsenic trioxide uptake by human and rat aquaglyceroporins.},
  author={Zijuan Liu and Jennifer M Carbrey and Peter Agre and Barry P. Rosen},
  journal={Biochemical and biophysical research communications},
  volume={316 4},
Aquaglyceroporins are channels that allow downhill movement of uncharged solutes such as glycerol and urea. Arsenic trioxide has recently been shown to be translocated by mouse mAQP7 and rat rAQP9. In this study we examined the ability of the four known human members of the aquaglyceroporin family, hAQP3, hAQP7, hAQP9, and hAQP10, to facilitate As(OH)(3) movement in Xenopus oocytes. The order of effectiveness as an As(III) transporter was found to be hAQP9 > hAQP7, with little or no transport… CONTINUE READING

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