Arsenic trioxide suppresses transcription of hTERT through down-regulation of multiple transcription factors in HL-60 leukemia cells.

@article{Zhang2015ArsenicTS,
  title={Arsenic trioxide suppresses transcription of hTERT through down-regulation of multiple transcription factors in HL-60 leukemia cells.},
  author={Yao Zhang and Miao Sun and Weiwei Shi and Qingling Yang and Chang-jie Chen and Zhiwei Wang and Xin Zhou},
  journal={Toxicology letters},
  year={2015},
  volume={232 2},
  pages={481-9}
}
Acute promyelocytic leukemia (APL) is largely caused by the t(15,17) chromosome translocation, leading to the production of the PML/retinoic acid receptor alpha fusion. All-trans retinoic acid (ATRA) and arsenic trioxide (ATO), as a monotherapy or combination therapy, have been successfully used to treat APL primarily by targeting the degradation of the… CONTINUE READING