Arsenic trioxide suppressed mantle cell lymphoma by downregulation of cyclin D1

@article{Lo2013ArsenicTS,
  title={Arsenic trioxide suppressed mantle cell lymphoma by downregulation of cyclin D1},
  author={Rico K. H. Lo and Yok-lam Kwong},
  journal={Annals of Hematology},
  year={2013},
  volume={93},
  pages={255-265}
}
Mantle cell lymphoma (MCL) is aggressive with poor prognosis. Due to t(11;14)(q13;q32), cyclin D1 is overexpressed. The in vitro activities of arsenic trioxide (As2O3) in MCL were investigated. In MCL lines Jeko-1 and Granta-519, As2O3 induced dose-dependent and time-dependent increases in apoptosis accompanied by cyclin D1 suppression. Downregulation of… CONTINUE READING