Arsenic trioxide sensitivity is associated with low level of glutathione in cancer cells

@article{Yang1999ArsenicTS,
  title={Arsenic trioxide sensitivity is associated with low level of glutathione in cancer cells},
  author={C-H Yang and M Y-P Kuo and J-C Chen and Y-C Chen},
  journal={British Journal of Cancer},
  year={1999},
  volume={81},
  pages={796 - 799}
}
Arsenic trioxide (As2O3) is a novel anticancer agent, which has been found to induce remission in acute promyelocytic leukaemic patients following daily intravenous administration. The therapeutic value of As2O3 in other cancers is still largely unknown. Cytotoxic tests in a panel of cancer cell lines showed that bladder cancer, acute promyelocytic leukaemic and gastrointestinal cancer cells were the most sensitive to As2O3 among 17 cell lines tested. Cellular glutathione (GSH) system plays an… CONTINUE READING
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