Arsenic trioxide phosphorylates c-Fos to transactivate p21(WAF1/CIP1) expression.

Abstract

An infamous poison, arsenic also has been used as a drug for nearly 2400 years; in recently years, arsenic has been effective in the treatment of acute promyelocytic leukemia. Increasing evidence suggests that opposite effects of arsenic trioxide (ATO) on tumors depend on its concentrations. For this reason, the mechanisms of action of the drug should be… (More)
DOI: 10.1016/j.taap.2008.08.015

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