Arsenic trioxide depletes cancer stem-like cells and inhibits repopulation of neurosphere derived from glioblastoma by downregulation of Notch pathway.

@article{Wu2013ArsenicTD,
  title={Arsenic trioxide depletes cancer stem-like cells and inhibits repopulation of neurosphere derived from glioblastoma by downregulation of Notch pathway.},
  author={Jianing Wu and Zhiyong Ji and Huailei Liu and Yaohua Liu and Dayong Han and Chen Shi and Changbin Shi and Chunlei Wang and Guang Yang and Xiaofeng Chen and Chen Shen and Huadong Li and Yunke Bi and Dongzhi Zhang and Shiguang Zhao},
  journal={Toxicology letters},
  year={2013},
  volume={220 1},
  pages={61-9}
}
Notch signaling has been demonstrated to have a central role in cancer stem-like cells (CSLCs) in glioblastoma multiforme (GBM). We have recently demonstrated the inhibitory effect of arsenic trioxide (ATO) on CSLCs in glioblastoma cell lines. In this study we used neurosphere recovery assay that measured neurosphere formation at three time points to assess… CONTINUE READING