Arsenic trioxide causes selective necrosis in solid murine tumors by vascular shutdown.

  title={Arsenic trioxide causes selective necrosis in solid murine tumors by vascular shutdown.},
  author={Young S. Lew and Stephan L Brown and Robert J. Griffin and Chang Won Song and Jae Ho Kim},
  journal={Cancer research},
  volume={59 24},
To investigate the antitumor action of arsenic trioxide in solid tumors, we carried out quantitative tumor perfusion studies, using locally advanced methylcholanthrene-induced fibrosarcoma grown in BALB/c mice. The tumor perfusion studies were assessed by two separate methods: 99mTc clearance and 86Rb uptake. A single administration of arsenic trioxide (10 mg/kg i.p.) produced a preferential vascular shutdown in the tumor tissue at 2 and 6 h, leading to massive necrosis in the central part of… CONTINUE READING


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