Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells.

@article{Li1999ArsenicTT,
  title={Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells.},
  author={Yuchi Li and John D. Broome},
  journal={Cancer research},
  year={1999},
  volume={59 4},
  pages={776-80}
}
Arsenic exhibits a differential toxicity to cancer cells. At a high concentration (>5 microM), As2O3 causes acute necrosis in various cell lines. At a lower concentration (0.5-5 microm), it induces myeloid cell maturation and an arrest in metaphase, leading to apoptosis. As2O3-treated cells have features found with both tubulin-assembling enhancers (Taxol) and inhibitors (colchicine). Prior treatment of monomeric tubulin with As2O3 markedly inhibits GTP-induced polymerization and microtubule… CONTINUE READING

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Apoptosis induced in premyelocytic leukemia cells by arsenic and proteasome inhibitors

  • Y. M. Li, J. D. Broome
  • Blood, 90 (Suppl
  • 1997
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