Arsenic stimulates release of cytochrome c from isolated mitochondria via induction of mitochondrial permeability transition.

@article{Bustamante2005ArsenicSR,
  title={Arsenic stimulates release of cytochrome c from isolated mitochondria via induction of mitochondrial permeability transition.},
  author={Juanita Bustamante and Leta K. Nutt and Sten Orrenius and Vladimir Gogvadze},
  journal={Toxicology and applied pharmacology},
  year={2005},
  volume={207 2 Suppl},
  pages={110-6}
}
Arsenic trioxide, As(III), is a known environmental toxicant, co-carcinogen, and potent chemotherapeutic agent. In model experiments with isolated rat liver mitochondria, As(III) stimulated a dose-dependent, cyclosporin A-sensitive release of cytochrome c via induction of mitochondrial permeability transition and subsequent swelling of mitochondria. Mitochondrial GSH does not seem to be a target for As(III) which, however, appears to cause oxidative modification of thiol groups of pore forming… CONTINUE READING