Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxide.

  title={Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxide.},
  author={Adam C. Straub and Katherine A. A. Clark and Mark A. Ross and Ashwin G Chandra and Song Li and Xiang Gao and Patrick J Pagano and Donna B Stolz and Aaron Barchowsky},
  journal={The Journal of clinical investigation},
  volume={118 12},
Environmental arsenic exposure, through drinking contaminated water, is a significant risk factor for developing vascular diseases and is associated with liver portal hypertension, vascular shunting, and portal fibrosis through unknown mechanisms. We found that the addition of low doses of arsenite to the drinking water of mice resulted in marked pathologic remodeling in liver sinusoidal endothelial cells (SECs), including SEC defenestration, capillarization, increased junctional PECAM-1… CONTINUE READING


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