Arsenic-specific stem cell selection during malignant transformation.

@article{Tokar2010ArsenicspecificSC,
  title={Arsenic-specific stem cell selection during malignant transformation.},
  author={Erik J. Tokar and Wei Qu and Jie Liu and Wei Liu and Mukta M. Webber and James Ming Phang and Michael P. Waalkes},
  journal={Journal of the National Cancer Institute},
  year={2010},
  volume={102 9},
  pages={638-49}
}
BACKGROUND Arsenic is a carcinogen that targets the urogenital system, including the prostate. Although the mechanisms for arsenic-induced carcinogenesis are undefined, arsenic drives overaccumulation of stem cells and cancer stem cells (CSCs) in vivo and in vitro, indicating that these cells are a key target population. Disruption of stem cell population dynamics may be critical to acquisition of cancer phenotype. We tested the hypothesis that prostate stem cells have a survival selection… CONTINUE READING
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