Arsenic speciation of arsine-exposed blood samples by high-performance liquid chromatography-inductively coupled plasma mass spectrometry and as-adduct, a possible indicator of AsH3 exposure.

@article{Higashikawa2008ArsenicSO,
  title={Arsenic speciation of arsine-exposed blood samples by high-performance liquid chromatography-inductively coupled plasma mass spectrometry and as-adduct, a possible indicator of AsH3 exposure.},
  author={Yoshiyasu Higashikawa and Yuko Kazui and Shinichi Suzuki and Osamu Ohtsuru},
  journal={Journal of analytical toxicology},
  year={2008},
  volume={32 5},
  pages={344-8}
}
Arsine (AsH(3))-exposed human blood samples were analyzed by high-performance liquid chromatography with inductively coupled plasma mass spectrometry (HPLC-ICP-MS) for arsenic speciation. After exposure of human blood samples to AsH(3) vapor for 90 min at room temperature, partial hemolysis was observed. Plasma samples from these whole blood samples were prepared by centrifugation at 1600 x g for 10 min and analyzed by HPLC-ICP-MS. In addition to arsenite [As(III); degraded from AsH(3)], an… CONTINUE READING

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