Arsenic-induced oxidative stress and its reversibility.

  title={Arsenic-induced oxidative stress and its reversibility.},
  author={Swaran J. S. Flora},
  journal={Free radical biology & medicine},
  volume={51 2},
This review summarizes the literature describing the molecular mechanisms of arsenic-induced oxidative stress, its relevant biomarkers, and its relation to various diseases, including preventive and therapeutic strategies. Arsenic alters multiple cellular pathways including expression of growth factors, suppression of cell cycle checkpoint proteins, promotion of and resistance to apoptosis, inhibition of DNA repair, alterations in DNA methylation, decreased immunosurveillance, and increased… CONTINUE READING
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