Arsenic disulfide synergizes with the phosphoinositide 3-kinase inhibitor PI-103 to eradicate acute myeloid leukemia stem cells by inducing differentiation.

@article{Hong2011ArsenicDS,
  title={Arsenic disulfide synergizes with the phosphoinositide 3-kinase inhibitor PI-103 to eradicate acute myeloid leukemia stem cells by inducing differentiation.},
  author={Zhenya Hong and Min Xiao and Y Yang and Zhiqiang Han and Yang Cao and Chunrui Li and Ying Ping Wu and Quan Yi Gong and Xiaoxi Zhou and Danmei Xu and Li Meng and Ding Ma and Jianfeng Zhou},
  journal={Carcinogenesis},
  year={2011},
  volume={32 10},
  pages={
          1550-8
        }
}
Although dramatic clinical success has been achieved in acute promyelocytic leukemia (APL), the success of differentiating agents has not been reproduced in non-APL leukemia. A key barrier to the clinical success of arsenic is that it is not potent enough to achieve a clinical benefit at physiologically tolerable concentrations by targeting the leukemia cell differentiation pathway alone. We explored a novel combination approach to enhance the eradication of leukemia stem cells (LSCs) by… CONTINUE READING

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