Arsenic compound-induced increases in glutathione levels in cultured Chinese hamster V79 cells and mechanisms associated with changes in γ-glutamylcysteine synthetase activity, cystine uptake and utilization of cysteine

@article{Ochi1997ArsenicCI,
  title={Arsenic compound-induced increases in glutathione levels in cultured Chinese hamster V79 cells and mechanisms associated with changes in γ-glutamylcysteine synthetase activity, cystine uptake and utilization of cysteine},
  author={Takafumi Ochi},
  journal={Archives of Toxicology},
  year={1997},
  volume={71},
  pages={730-740}
}
Increases in the glutathione (GSH) level in cultured Chinese hamster V79 cells incubated with arsenic compounds were investigated in terms of changes in the activity of γ-glutamylcysteine synthetase (γ-GCS), rate of cystine uptake, and utilization of cysteine. Arsenite at subtoxic concentrations caused a marked increase of the GSH level at 8 h after addition and then declined. Increase in the GSH level caused by arsenite was associated with an increase in the rate of cystine uptake, but not in… CONTINUE READING
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Selective modi®cation of glutathione metabolism

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